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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Indomethacin
supplement:
Masoprocol
Research Papers that Mention the Interaction
“ConclusionsWe have shown that indomethacin stimulation of macrophage cytostasis against MOPC-315 tumor cells can be counteracted by PGE2 and by the lipoxygenase inhibitor NDGA.”
Indomethacin stimulation of macrophage cytostasis against MOPC-315 tumor cells is enhanced by endogenous metabolites of lipoxygenase and counteracted by prostaglandin E2“Control synthesis by erythrocytes and thrombocytes was inhibited by 5 microM indomethacin (cyclooxygenase pathway) or nordihydroguaiaretic acid (5-lipoxygenase pathway) and cyclooxygenase products were increased in the presence of nordihydroguaiaretic acid.”
“Furthermore, the release of NCF and ECF was suppressed by preincu-bating the slices with nordihydroguaiaretic acid (50 μM), a 5-lipoxygenase inhibitor, and enhanced with indo-methacin (8.5 μM), a cyclooxygenase inhibitor.”
“ Indomethacin and nordihydroguaiaretic acid synergistically potentiated TNF-alpha-induced apoptosis, while arachidonic acid, AACOCF3 and MK-886 did not modulate its effects.”
“In the majority of cases, indomethacin augmented LAK cell induction in the TIL (P = 0.073 for the entire group, compared with cultures not treated with indomethacin) and nordihydroguaiaretic acid (NDGA) depressed LAK cell induction (P < 0.05 for the entire group, compared with cultures not treated with NDGA).”
“This activity is partially inhibited by the lipoxygenase inhibitor nordihydroguaiaretic acid and the thromboxane synthetase inhibitor OKY-1581, but is augmented by indomethacin.”
“The formation of lipoxygenase products in all tissues was markedly inhibited by nordihydroguaiaretic acid (NDGA) an inhibitor of lipoxygenase activity and slightly stimulated or inhibited by indomethacin , an inhibitor of cyclooxygenase activity.”
“However, when added in the background of indomethacin, NDGA caused significant reversal of the IAS tone.”
Arachidonic acid metabolites follow the preferential course of cyclooxygenase pathway for the basal tone in the internal anal sphincter.“administered lipoxygenase inhibitors (phenidone, BW755c and NDGA ) and indomethacin independently inhibited thisin vivo response.”
“Prostaglandin E2 and nordihydroguaiaretic acid also inhibited indomethacin stimulation of macrophage thymidine incorporation.”
“The effect of indomethacin was inhibited by prostaglandin E2 and by the lipoxygenase inhibitor nordihydroguaiaretic acid.”
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