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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Indomethacin
supplement:
Genistein
Research Papers that Mention the Interaction
“Steroid hormones (17beta-estradiol, progesterone and cortisol), flavonoids genistein and quercetin) and non-steroidal anti-inflammatory drugs (NSAIDs) ( indomethacin and diclofenac) inhibit [(14)C]AA uptake in a dose-dependent and non-competitive manner.”
Expression and characterization of vitamin C transporter in the human trophoblast cell line HTR-8/SVneo: effect of steroids, flavonoids and NSAIDs.“However, the anticancer activity of genistein was much weaker than that of indomethacin (non-selective COX inhibitor), celecoxib and baicalein (flavonoid isolated from Scutellaria baicalensis).”
“ Indomethacin reduced in half the inhibition of platelet aggregation elicited by genistein.”
Effect of genistein and raloxifene on vascular dependent platelet aggregation“In the presence of atenolol, quinacrine, an inhibitor of phospholipase A2, and metyrapone, an inhibitor of P-450 enzymes, but not alpha-naphthoflavone, an inhibitor of P-450 enzymes, indomethacin , a cyclooxygenase inhibitor, or AA861, a 5-lipoxygenase inhibitor, inhibited the potentiating effect of genistein.”
“The protein kinase C and A inhibitors, H-7 and H-8, or the cyclooxygenase inhibitor, indomethacin , had no effect upon 14,15-EET-induced [3H]thymidine incorporation, but the selective tyrosine kinase inhibitor, genistein , significantly inhibited it.”
“ Indomethacin (10 micromol/L), a blocker of prostaglandin biosynthesis, reduced salidiuresis and renal vasorelaxation by genistein.”
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