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Last Updated: 2 years ago

Possible Interaction: Indomethacin and Genistein

supplement:

Genistein

Research Papers that Mention the Interaction

Steroid hormones (17beta-estradiol, progesterone and cortisol), flavonoids genistein and quercetin) and non-steroidal anti-inflammatory drugs (NSAIDs) ( indomethacin and diclofenac) inhibit [(14)C]AA uptake in a dose-dependent and non-competitive manner.
Molecular human reproduction  •  2007  |  View Paper
However, the anticancer activity of genistein was much weaker than that of indomethacin (non-selective COX inhibitor), celecoxib and baicalein (flavonoid isolated from Scutellaria baicalensis).
Cancer letters  •  2004  |  View Paper
Indomethacin reduced in half the inhibition of platelet aggregation elicited by genistein.
Molecular and Cellular Endocrinology  •  2007  |  View Paper
In the presence of atenolol, quinacrine, an inhibitor of phospholipase A2, and metyrapone, an inhibitor of P-450 enzymes, but not alpha-naphthoflavone, an inhibitor of P-450 enzymes, indomethacin , a cyclooxygenase inhibitor, or AA861, a 5-lipoxygenase inhibitor, inhibited the potentiating effect of genistein.
Journal of cardiovascular pharmacology  •  2000  |  View Paper
The protein kinase C and A inhibitors, H-7 and H-8, or the cyclooxygenase inhibitor, indomethacin , had no effect upon 14,15-EET-induced [3H]thymidine incorporation, but the selective tyrosine kinase inhibitor, genistein , significantly inhibited it.
The Journal of Biological Chemistry  •  1998  |  View Paper
Indomethacin (10 micromol/L), a blocker of prostaglandin biosynthesis, reduced salidiuresis and renal vasorelaxation by genistein.
Hypertension  •  1998  |  View Paper