Possible Interaction: Indomethacin and Eicosatrienoic Acid

“ Indomethacin reduced the effect of the DGLA.”

“ Indomethacin , by blocking platelet cyclooxygenase, prevents the activation of phospholipase C, protein kinase C, and platelet shape change induced by dihomogammalinolenic acid.”

“Pretreatment of the smooth muscle strips with indomethacin inhibited the effect of arachidonic acid and dihomo-γ-linolenic acid.4.The PG endoperoxides PGG2 and PGH2 as well as their derivative prostacyclin (PGI2) were more effective than arachidonic acid as inhibitors of noradrenaline-induced contractions.”

“Furthermore, it can be assumed that a part of the inhibitory effect of DGLA is due to the effect of a cyclooxygenase product, probably PGE(1), because indomethacin reduced the inhibitory effect of DGLA.”

“Further studies on intact arteries demonstrated that eicosatriynoic acid not only blocked the vasodilatory response to H2O2 but unmasked a vasoconstrictor effect that was reversed by blocking cyclooxygenase activity with indomethacin.”

“Although the enzyme converted Mead acid to products more slowly and less completely than the isomeric 8,11,14-icosatrienoic acid, both oxidations were inhibitable by indomethacin.”

“The bronchoconstrictive responses to DGLA were abolished by prior inhibition of the cyclooxygenase with indomethacin.”

“ DGLA and AA vascular responses were blocked by indomethacin.”

“Intraarterial infusion of the prostaglandin synthesis inhibitors eicosa-5,8,11,14 tetraynoic acid (ETA) or indomethacin antagonized the depressant effect of DHL on the vasoconstrictor response to norepinephrine.”

“Further studies on intact arteries demonstrated that eicosatriynoic acid not only blocked the vasodilatory response to H2O2but unmasked a vasoconstrictor effect that was reversed by blocking cyclooxygenase activity with indomethacin.”