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Last Updated: 2 years ago

Possible Interaction: Indomethacin and Eicosatrienoic Acid

Research Papers that Mention the Interaction

Indomethacin reduced the effect of the DGLA.
Arthritis and rheumatism  •  1989  |  View Paper
Indomethacin , by blocking platelet cyclooxygenase, prevents the activation of phospholipase C, protein kinase C, and platelet shape change induced by dihomogammalinolenic acid.
Biochimica et biophysica acta  •  1984  |  View Paper
Pretreatment of the smooth muscle strips with indomethacin inhibited the effect of arachidonic acid and dihomo-γ-linolenic acid.4.The PG endoperoxides PGG2 and PGH2 as well as their derivative prostacyclin (PGI2) were more effective than arachidonic acid as inhibitors of noradrenaline-induced contractions.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2004  |  View Paper
Furthermore, it can be assumed that a part of the inhibitory effect of DGLA is due to the effect of a cyclooxygenase product, probably PGE(1), because indomethacin reduced the inhibitory effect of DGLA.
Pharmacology  •  2000  |  View Paper
Further studies on intact arteries demonstrated that eicosatriynoic acid not only blocked the vasodilatory response to H2O2 but unmasked a vasoconstrictor effect that was reversed by blocking cyclooxygenase activity with indomethacin.
The American journal of physiology  •  1998  |  View Paper
Although the enzyme converted Mead acid to products more slowly and less completely than the isomeric 8,11,14-icosatrienoic acid, both oxidations were inhibitable by indomethacin.
The Journal of biological chemistry  •  1986  |  View Paper
The bronchoconstrictive responses to DGLA were abolished by prior inhibition of the cyclooxygenase with indomethacin.
Prostaglandins, leukotrienes, and medicine  •  1983  |  View Paper
DGLA and AA vascular responses were blocked by indomethacin.
The Journal of pharmacology and experimental therapeutics  •  1977  |  View Paper
Intraarterial infusion of the prostaglandin synthesis inhibitors eicosa-5,8,11,14 tetraynoic acid (ETA) or indomethacin antagonized the depressant effect of DHL on the vasoconstrictor response to norepinephrine.
Prostaglandins  •  1974  |  View Paper
Further studies on intact arteries demonstrated that eicosatriynoic acid not only blocked the vasodilatory response to H2O2but unmasked a vasoconstrictor effect that was reversed by blocking cyclooxygenase activity with indomethacin.
American journal of physiology. Heart and circulatory physiology  •  1998  |  View Paper
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