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Discover Supplement-Drug Interactions

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Last Updated: 6 months ago

Possible Interaction: Indomethacin and Beta-Glucans

supplement:

Beta-Glucans

Research Papers that Mention the Interaction

The administration of beta-glucan (sonifilan; SPG) in combination with a non-steroidal anti-inflammatory drug, indomethacin (IND), induced lethal septic shock in mice.
Microbial pathogenesis  •  2008  |  View Paper
Stimulation with the proteinases did not alter the PGE2 levels … supernatants from 24-h cultures of PL, however, beta-glucans (100 microg ml(-1)) provoked a large increase in PGE2 levels, … were inhibited after addition of 10 microg ml(-1) of indomethacin , a non-selective inhibitor … COX2 enzymatic activity.
Fish & shellfish immunology  •  2007  |  View Paper
Combination of a beta-glucan and IND increased the number of leukocytes, especially macrophages and neutrophils, in various organs and these cells were activated.
We have found that the combination of a beta-glucan and a non-steroidal anti-inflammatory drug (NSAID), indomethacin (IND), induced lethal toxicity in mice [Yoshioka et al. (1998) FEMS Immunol.
FEMS immunology and medical microbiology  •  2001  |  View Paper
In this study, we found that the combination of a beta-glucan and a nonsteroidal anti-inflammatory drug, indomethacin , induced lethal toxicity in mice.
FEMS immunology and medical microbiology  •  1998  |  View Paper