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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Indomethacin
supplement:
Beta-Glucans
Research Papers that Mention the Interaction
“The administration of beta-glucan (sonifilan; SPG) in combination with a non-steroidal anti-inflammatory drug, indomethacin (IND), induced lethal septic shock in mice.”
SPG/IND-induced septic shock in a LPS-low responder strain, C3H/HeJ mice.“Stimulation with the proteinases did not alter the PGE2 levels … supernatants from 24-h cultures of PL, however, beta-glucans (100 microg ml(-1)) provoked a large increase in PGE2 levels, … were inhibited after addition of 10 microg ml(-1) of indomethacin , a non-selective inhibitor … COX2 enzymatic activity.”
“Combination of a beta-glucan and IND increased the number of leukocytes, especially macrophages and neutrophils, in various organs and these cells were activated.”
“We have found that the combination of a beta-glucan and a non-steroidal anti-inflammatory drug (NSAID), indomethacin (IND), induced lethal toxicity in mice [Yoshioka et al. (1998) FEMS Immunol.”
“In this study, we found that the combination of a beta-glucan and a nonsteroidal anti-inflammatory drug, indomethacin , induced lethal toxicity in mice.”
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