Possible Interaction: Indomethacin and Arachidonate

“However, the arachidonate induced coronary relaxation was inhibited by pretreatment with PG synthetase inhibitors, indomethacin , meclofenemate and aspirin.”

“ Indomethacin addition to the strips previously relaxed by arachidonate caused contraction.”

“Incubation with indomethacin abolished the generation of thromboxane B2 after stimulation with arachidonate , but had no effect on the stimulation with ristocetin, during which no TxB2 was produced.”

“ Indomethacin enhanced AA induced aggregation, whereas 1-methylimidazole inhibited aggregation and LDH release.”

“Inhibition of cyclo-oxygenase by indomethacin prevented the initial pressure drop to arachidonate , but not the sustained increase in pressure.”

“BP-II was found to elicit a strong contraction of guinea pig ileum, and this activity was inhibited completely by 1 microM indomethacin , an inhibitor of the arachidonate cascade.”

“Our results suggest a possible link between arachidonate metabolites inhibited by indomethacin or dexamethasone and the genesis of cytochrome P-450 disfunction.”

“In the present study, the following additional evidences were demonstrated: 1) Captopril did not increase 6-keto-PGF1 alpha level in the deficient strain, … soybean trypsin inhibitor with carrageenin markedly suppressed the exudate volume and levels of 6-keto-PGF1 alpha in the normal strain; and 3) indomethacin … arachidonate ….”

“The cyclooxygenase inhibitor, indomethacin , induced suppressions of 39% for 150 nmol AA and 22% for 300 nmol AA, respectively.”

“The metabolic and hemodynamic actions of arachidonate were inhibited specifically by Indo.”

“Contractions to arachidonate were inhibited by indomethacin (0.5 and 5 μg/ml) and by aspirin (5 and 50 μg/ml).”