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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Indomethacin
supplement:
Alpha-lipoic acid
Research Papers that Mention the Interaction
“Both classical analgesics (nonsteroidal anti-…, phenytoin or carbamazepine and α-lipoic acid can modulate the balance … of drugs such as indomethacin , meloxicam, tenoxicam, valdecoxib or some metabolites of analgesic drugs formed by the activity of …, including gastrointestinal ulcers, hepatic failure, agranulocytosis, aplastic anemia, neutropenia, opiate-induced hyperalgesia and tolerance.”
Nitrogen, oxygen or sulfur containing heterocyclic compounds as analgesic drugs used as modulators of the nitroxidative stress.“ Thioctic acid protection was suppressed by pretreatment with indomethacin (30 mg/kg), a cyclooxygenase inhibitor, and iodoacetamide (100 mg/kg), a sulfhydryl blocker.”
Thioctic acid protection against ethanol-induced gastric mucosal lesions involves sulfhydryl and prostaglandin participation.
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