Possible Interaction: Indole and Tryptophan

“ Indole constitutes a major component of the side chain of the amino acid tryptophan.”

“We suggest that exogenously applied indole and side-chains of the tryptophan residues of the channel protein involved in activation may compete for the same effector position and that indole might be useful as a probe to study functional roles of tryptophan residues.”

“The use of a membrane inlet triple quadrupole mass spectrometer revealed indole as an end product in the growth medium of cultures of the cattle parasite Tritrichomonas foetus and the human parasite Trichomonas vaginalis: formation of indole is enhanced in the presence of added tryptophan.”

“Abstract— The fact that most proteins contain several tryptophans hinders the investigation of the photochemistry of a particular indole residue.”

“Similarly, the addition of L-tryptophan to the medium induced the production of benzaldehyde, 1-octen-3-ol and indole.”

“Results: L-tryptophan production increased by 15 folds, when indole was used as an inducer.”

“F. nucleatum biofilm formation and the biofilm supernatant concentration of indole increased dose dependently with increasing tryptophan concentrations.”

“However, in the case of violacein, one of the tryptophans experiences an unusual 1→2 shift of the indole ring.”

“Addition of anthranilate, indole or tryptophan to the medium produces a fifteen- to forty-fold increase in tryptophan pool , but causes no repression of the biosynthetic enzymes.”

“The cyclic tautomer is an aniline derivative and the enamine reactivity of the indole ring in tryptophan is protected.”

“Analogs with modifications of the indole ring repressed the trp operon to various degrees.”