Possible Interaction: Indole and Threonine

“10-fold) was observed in the indole series using isoform-selective transient THR transfection assays.”

“Structural data identify a novel product binding site, and kinetic experiments clarify the atypical mechanism of specificity: Thr binds efficiently but decreases the affinity for indole and disrupts the allosteric signaling that regulates the catalytic cycle.”