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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Indole
drug:
Tetracycline
Research Papers that Mention the Interaction
“Interestingly, at the fed state, TET could increase the synthesis of indole and phenyl derivatives including indole-3-aldehyde and hydrocinnamate, while inhibiting indoxyl, tryptamine, and vitamin B production, all of which have host health implications.”
Feeding state greatly modulates the effect of xenobiotics on gut microbiome metabolism: A case study of tetracycline.“The combined results demonstrated that indole enhanced the tetracycline resistance of V. splendidus, and this resistance was probably due to upregulation of the outer membrane porin OmpN.”
“The percentage of … 10 μg/mL tetracycline was 600-fold higher in the culture with … of approximately 2.0 (higher level of indole ) than that in the culture with an OD600 of 0.5, which also … the level of indole was correlated to the tetracycline resistance of V. splendidus.”
Indole contributes to tetracycline resistance via the outer membrane protein OmpN in Vibrio splendidus.
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