Possible Interaction: Indole and Serine

“A small amount of skatole (SKT) (1.1 and 2.5% in B and BP, respectively) and p-cresol (CRL) (2.4 and 3.4% in B and BP, respectively) were also produced from IND plus Ser during 12-h incubation.”

“Although Class II enzymes have drastically reduced activity in the reaction of L-serine with indole and an altered distribution of enzyme-substrate intermediates in the reaction of L-serine with β-mercaptoethanol, they retain activity in the reaction of β-chloro-L-alanine with indole.”

“Cleavage of indoleglycerol phosphate (alpha reaction) was found to be associated with a delta H value of 54.0 +/- 2.5 kJ mol-1, while condensation of indole with L-serine (beta reaction) involved -80.3 +/- 4.6 kJ mol-1'.”

“ Indole employed with serine was more suitable for the production of auxins than indole or anthranilic acid used separately.”

“… serine stimulates the growth of L. … in the presence of indole (Schweigert, 1947), it has been concluded (Rydon, 1948; Work and Work, 1948) that, as in Neurospora, indole is condensed with serine to yield tryptophan by this organism and, moreover, that anthranilic acid is probably the precursor of indole.”

“For example, MITCHELL and LEIN (1948) have shown that a single gene change completely prevents any measurable activity of the enzyme which catalyzes the coupling of serine and indole to form tryptophane in Neurospora.”