Possible Interaction: Indole and Melatonin

“In the presence of the indole , a decrease in the GSH/GSSG ratio was observed that depended on the concentration of melatonin used.”

“ Melatonin blocked nuclear translocation of androgen receptor (AR), thus confirming anti‐androgenic actions of the indole.”

“Abrogation of the lipid signaling pathway by the indole reveals novel molecular pathways that may account for the protective effect of melatonin in liver fibrogenesis.”

“Finally, the antiestrogenic actions of melatonin could contribute to the ability of the indole of curtail the proliferation of some hormone-responsive breast tumors [13].”

“In animal experiments, feeding melatonin-containing foods raised blood levels of the indole.”

“Inhibition of the lipid signaling pathway by the indole reveals novel molecular pathways that may account for the protective effect of melatonin in this animal model of ALF, and supports the potential of melatonin as an antiviral agent.”

“The design and expeditious synthesis of two new indole analogs with up to 5-fold potency of that of melatonin is described.”

“In these models, the melatonin side chain can adopt a gauche/anti conformation out of the indole plane.”

“It appears that the anticonvulsant effects of melatonin occur only after the animals are chronically exposed to the indole.”

“These results demonstrate that morning injections of melatonin can prevent the antigonadotropic effects of afternoon melatonin injections and provide support for the hypothesis that the paradoxical actions of melatonin may be related to the ability of the indole to regulate its own receptors.”