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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Indole
drug:
Alpha-Chymotrypsin
Research Papers that Mention the Interaction
“Imprinting of lyophilized alpha-chymotrypsin with indole or sorbitol increased the reactivity of the active-site histidine towards iodomethane.”
Imprinting of lyophilized alpha-chymotrypsin affects the reactivity of the active-site imidazole.“The binding of indole to the specificity site of alpha-chymotrypsin causes both histidine residues to become less reactive.”
Properties of the histidine residues of indole-chymotrypsin. Implications for the activation process and catalytic mechanism.“Additionally, 5 mM indole was observed to behave as a strict competitive inhibitor of the alpha-chymotrypsin-catalyzed hydrolysis of BzTyrSBzl but was observed to increase the maximal rate of hydrolysis of p-nitrophenyl acetate by alpha-chymotrypsin by 30%, as previously described.”
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