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Last Updated: 3 years ago

Possible Interaction: Indole-3-Carbinol and Diindolylmethane



Research Papers that Mention the Interaction

Mean Cmax for DIM increased from 61 ng/mL at the 400-mg I3C dose to 607 ng/mL following a 1,000-mg dose.
Cancer Epidemiology Biomarkers & Prevention  •  2006  |  View Paper
Treatment of the T-ALL cell lines CCRF-CEM, CCRF-HSB2, SUP-T1 and Jurkat with DIM in vitro significantly reduced cell proliferation and viability at concentrations 8- to 25-fold lower than the parent compound I3C.
PloS one  •  2012  |  View Paper
Indole-3-carbinol is highly unstable and, therefore, the observed protection likely results from condensation products of indole-3-carbinol, e.g. diindolylmethane or indolo[3,2-b]carbazole (ICZ).
Archives of Toxicology  •  2016  |  View Paper
At the molecular level, I3C and DIM markedly inactivated extracellular signal-regulated kinase 1/2 (ERK1/2) and the inhibitory effect of DIM was significantly greater than that of I3C.
These results indicate that I3C and DIM had a differential potential in the regulation of the 2 principal survival signals, ERK1/2 and Akt, in endothelial cells.
The Journal of nutrition  •  2010  |  View Paper
The increase in DNA damage by DIM raises potential safety risks for dietary supplements of DIM and its precursor indole-3-carbinol.
Toxicological sciences : an official journal of the Society of Toxicology  •  2009  |  View Paper
DIM significantly down-regulated pErk, and I3C down-regulated NFκB, pIκBα protein expressions, and reduced portosystemic shunting degree.
International journal of molecular sciences  •  2019  |  View Paper