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Discover Supplement-Drug Interactions

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Last Updated: 3 months ago

Possible Interaction: Indapamide and Calcium Supplement

Research Papers that Mention the Interaction

Indapamide reduces intracellular calcium levels, maintains magnesium ions, but reduces phosphate ions that may be involved in arterial rigidity.
The American journal of cardiology  •  1990  |  View Paper
During intravenous calcium loading (0.375 mmol/kg body weight) 6 normal subjects after a single oral dose of indapamide excreted less calcium , suggesting a direct renal hypocalciuric action by the drug.
Pharmacology  •  1988  |  View Paper
A sulfonamide moiety is also present in the nonthiazide diuretics metolazone and indapamide (not shown), and these agents are also known to affect CA activity.
Hypertension  •  2010  |  View Paper
Indapamide (3 x 10(-4) M) depressed both inward calcium and outward potassium currents.
  •  1988  |  View Paper
These drugs … range) some CA isozymes involved in critical physiologic processes, among the 16 present in vertebrates, for … VII, XII, and XIII, chlorthalidone against CA VB, VII, IX, XII, and XIII, indapamide against CA VII, IX, XII, and XIII, furosemide against … XIV, and bumetanide against CA IX and XII.
Bioorganic & medicinal chemistry letters  •  2008  |  View Paper
It has also been … observed beneficial effect of indapamide for the treatment of patients with hypertension and … might be due to its potent inhibition of CA isoforms present in kidneys and blood vessels, which would thus explain both … lowering effects as well as organ-protective activity of the drug.
Current pharmaceutical design  •  2008  |  View Paper
Indapamide shows an alteration in vascular reactivity to calcium and other agonists, suggesting the possibility of a direct vascular effect.
American heart journal  •  1983  |  View Paper
Treatment of rats having received MCT with Indapamide reduced calcium uptake by diaphragmatic strips to levels that are not significantly different from the control (P > 0.05).
Toxicology letters  •  1999  |  View Paper
IDP decreased and increased, respectively, calcium and sodium excretions.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research  •  1998  |  View Paper
Indapamide also slightly reduced the effect of the calcium agonist Bay K 8644, which increases intracellular calcium through voltage operated calcium channels.
Indapamide antagonizes the effects of increases in extracellular potassium and calcium while hydrochlorothiazide has the opposite effect on the cardiac response to increases in [K+]0 or [Ca2+]0.
General pharmacology  •  1993  |  View Paper
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