Possible Interaction: Indapamide and Calcium Supplement

“These drugs … range) some CA isozymes involved in critical physiologic processes, among the 16 present in vertebrates, for … VII, XII, and XIII, chlorthalidone against CA VB, VII, IX, XII, and XIII, indapamide against CA VII, IX, XII, and XIII, furosemide against … XIV, and bumetanide against CA IX and XII.”

“It has also been … observed beneficial effect of indapamide for the treatment of patients with hypertension and … might be due to its potent inhibition of CA isoforms present in kidneys and blood vessels, which would thus explain both … lowering effects as well as organ-protective activity of the drug.”

“ Indapamide shows an alteration in vascular reactivity to calcium and other agonists, suggesting the possibility of a direct vascular effect.”

“During intravenous calcium loading (0.375 mmol/kg body weight) 6 normal subjects after a single oral dose of indapamide excreted less calcium , suggesting a direct renal hypocalciuric action by the drug.”

“Treatment of rats having received MCT with Indapamide reduced calcium uptake by diaphragmatic strips to levels that are not significantly different from the control (P > 0.05).”

“ IDP decreased and increased, respectively, calcium and sodium excretions.”

“ Indapamide is a potent Ca2+ antagonist.”

“ Indapamide antagonizes the effects of increases in extracellular potassium and calcium while hydrochlorothiazide has the opposite effect on the cardiac response to increases in [K+]0 or [Ca2+]0.”

“Moreover, in vitro studies have demonstrated that indapamide decreases the inward calcium current and the transmembrane influx of calcium.”

“Also in the frog heart, 0.03 mM indapamide reduced the stimulatory effects of isoproterenol and calcium ion and enhanced the inhibitory action of acetylcholine.”