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“ Chronic imipramine treatment caused increases in l-methionine, l-tyrosine , and l-lysine in the cerebral cortex, and an increase in l-aspartate in the hypothalamus.”
“When rats were injected with IMI 4.5 hr before 200 mg/kg of tyrosine and 5.5 hr before being killed, the elevation in brain pHPG levels were attenuated by about 50%, as compared to the animals that received tyrosine alone.”