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Last Updated: 2 years ago

Possible Interaction: Imipramine and Tryptophan

supplement:

Tryptophan

Research Papers that Mention the Interaction

Imipramine was found to have direct competition with L-tryptophan , which indicated that imipramine was interacting with Sudlow site II, or the indole-benzodiazepine site of HSA.
The association equilibrium constant found for imipramine at its site of competition with L-tryptophan also agreed with the value that was obtained for the major binding site of imipramine in the frontal analysis studies.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences  •  2009  |  View Paper
In the frontoparietal cortex of the rat the in vivo activity of tryptophan and tyrosine hydroxylase were equipotently attenuated by imipramine , while the selective blocker of the uptake of noradrenaline, desipramine and the selective blocker of the uptake of serotonin, citalopram, reduced only tyrosine or tyrosine hydroxylase respectively.
Neuropharmacology  •  1992  |  View Paper
Imipramine also significantly increased hypothalamic 5HT and TP concentrations.
Chronobiology international  •  1988  |  View Paper
Chronic imipramine treatment completely abolished the increase in serotonin turnover induced by tryptophan , but had no effect on serotonin turnover in mice treated with p-chlorophenylalanine, which itself reduced serotonin activity.
General pharmacology  •  1985  |  View Paper
administration of imipramine and nomifensine increased the affinity of mesencephalic tryptophan hydroxylase for tryptophan.
Arzneimittel-Forschung  •  1980  |  View Paper
It was found that imipramine and particularly chlorimipramine potentiated the effects of 5-hydroxytryptophan, tryptophan and nialamide on the extensor hindlimb reflex.
European journal of pharmacology  •  1970  |  View Paper