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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Imipramine
supplement:
St John's Wort
Research Papers that Mention the Interaction
“We also suggest that patients be questioned regarding concomitant use of St. John’s wort with other CYP1A2 substrates such as R-warfarin, clozapine, olanzapine, clomipramine, and imipramine.”
Potential Metabolic Interaction between St. John's Wort and Theophylline“Co-administration of John's wort (200 mg/kg, P. O.) with imipramine (10 mg/kg, I. P.) further improved body weight, locomotor activity, antianxiety effect as well as reduced oxidative damage in sleep-deprived animal as compared to their effect per se (P < 0.05).”
Protective effect of St. John's wort (Hypericum perforatum) extract on 72-hour sleep deprivation-induced anxiety-like behavior and oxidative damage in mice.
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