supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Imipramine
supplement:
S-Adenosylmethionine
Research Papers that Mention the Interaction
“A double-blind clinical trial was carried out to evaluate the efficacy of S-adenosyl-L-methionine (SAMe) in speeding the onset of action of imipramine (IMI).”
Efficacy of S-adenosyl-L-methionine in speeding the onset of action of imipramine“ S-adenosyl-L-methionine (SAM) has shown efficacy in speeding the onset of the antidepressant effect of imipramine in depressed patients.”
“ SAM prevents the 5-HT(1A) receptor up-regulation induced by acute imipramine in the frontal cortex.”
S-adenosyl-l-methionine prevents 5-HT1A receptors up-regulation induced by acute imipramine in the frontal cortex of the rat“A similar but long-lasting depletion of S-adenosyl-L-methionine was obtained after chronic treatment with imipramine or after a single dose of cycloleucine, a drug that interferes with the synthesis of S-adenosyl-L-methionine from methionine.”
“One study showed that SAMe was significantly better than placebo in accelerating the response to imipramine from day 4 to day 12, but the mean scores were not statistically different at the day 14 endpoint.”
S-Adenosylmethionine (SAMe) in major depressive disorder (MDD): a clinician-oriented systematic review
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback