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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Imipramine
supplement:
Quinidine
Research Papers that Mention the Interaction
“During quinidine the total oral clearance of imipramine on average was reduced by 35%, and that of desipramine by 85%.”
Quinidine inhibits the 2-hydroxylation of imipramine and desipramine but not the demethylation of imipramine“We also examined the effect of the CYP2D6 inhibitor quinidine , the CYP3A inhibitor ketoconazole, and the dopamine reuptake inhibitor GBR-12935 for their ability to inhibit P450 2D18-mediated metabolism of imipramine.”
“Both activities of desipramine and imipramine 2-hydroxylase were markedly inhibited by quinidine but not by quinine.”
“ Quinidine was a potent inhibitor of the … site for the 2-hydroxylation of imipramine in microsomes from all three human livers, with apparent Ki-values ranging from 9 to 92 nM. This … strongly suggests that the high affinity enzyme is CYP2D6, the source of the sparteine/debrisoquine oxidation polymorphism.”
“On the other hand, lipophilic cationic drugs, such as clonidine, bisoprolol, diphenhydramine, pyrilamine, and imipramine , significantly decreased the uptake of quinidine in MDCK cells.”
Presence of an H+/Quinidine Antiport System in Madin–Darby Canine Kidney Cells“ Quinidine inhibited the hydroxylation of imipramine competitively by 60% and 98% at concentrations of 10 microM and 100 microM, respectively.”
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