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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Imipramine and Quinidine



Research Papers that Mention the Interaction

During quinidine the total oral clearance of imipramine on average was reduced by 35%, and that of desipramine by 85%.
European Journal of Clinical Pharmacology  •  2004  |  View Paper
We also examined the effect of the CYP2D6 inhibitor quinidine , the CYP3A inhibitor ketoconazole, and the dopamine reuptake inhibitor GBR-12935 for their ability to inhibit P450 2D18-mediated metabolism of imipramine.
Archives of biochemistry and biophysics  •  1998  |  View Paper
Both activities of desipramine and imipramine 2-hydroxylase were markedly inhibited by quinidine but not by quinine.
Biological & pharmaceutical bulletin  •  1993  |  View Paper
Quinidine was a potent inhibitor of the … site for the 2-hydroxylation of imipramine in microsomes from all three human livers, with apparent Ki-values ranging from 9 to 92 nM. This … strongly suggests that the high affinity enzyme is CYP2D6, the source of the sparteine/debrisoquine oxidation polymorphism.
British journal of clinical pharmacology  •  1992  |  View Paper
On the other hand, lipophilic cationic drugs, such as clonidine, bisoprolol, diphenhydramine, pyrilamine, and imipramine , significantly decreased the uptake of quinidine in MDCK cells.
European Journal of Drug Metabolism and Pharmacokinetics  •  2015  |  View Paper
Quinidine inhibited the hydroxylation of imipramine competitively by 60% and 98% at concentrations of 10 microM and 100 microM, respectively.
Brain Research  •  1996  |  View Paper