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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Imipramine
supplement:
Progesterone
Research Papers that Mention the Interaction
“ Imipramine , desipramine, mazindol, and GBR12909 competitively inhibited PROG 21-hydroxylation mediated by CYP2D4 and/or CYP2D6, and all psychotropic drugs inhibited ALLO 21-hydroxylation mediated by CYP2D4 and/or CYP2D6.”
“The inhibition constants (Ki values) of imipramine , desipramine, and mazindol against the 21-hydroxylation of PROG and ALLO by CYP2D6 were lower than those by CYP2D4.”
Effect of psychotropic drugs on the 21-hydroxylation of neurosteroids, progesterone and allopregnanolone, catalyzed by rat CYP2D4 and human CYP2D6 in the brain.“Ovarian hormones estradiol and progesterone were found to affect the concentration and affinity of imipramine binding sites in the hypothalamus but not the cortex of female rats.”
Direct effects of ovarian hormones on antidepressant binding sites
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