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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Imipramine and Phosphatidylinositol 4,5-Diphosphate

Research Papers that Mention the Interaction

5 Our findings suggest that PLC is the target for IMI, that recovery of IM needs lipid phosphorylation for PIP2 resynthesis, and that IMI inhibits IM by activating a PLC‐dependent pathway, likely by decreasing the concentration of PIP2.
Also, when we applied phosphatidylinositol 4,5‐bisphosphate (PIP2) intracellularly, it diminished the inhibition of IM by IMI.
British journal of pharmacology  •  2005  |  View Paper