Possible Interaction: Imipramine and Methionine

“ Chronic imipramine treatment caused increases in l-methionine , l-tyrosine, and l-lysine in the cerebral cortex, and an increase in l-aspartate in the hypothalamus.”

“Contrary to this, the concentrations of l-aspartate, l-serine, l-asparagine, glycine, l-glutamine, gamma-aminobutyric acid, l-threonine, l-arginine, l-proline, l-valine, and l-methionine in the hippocampus were decreased by chronic imipramine treatment.”

“The administration of morphine M ) plus CLO, MAP, IMI or ZIM resulted in a significant additive effect that was antagonized by 1 or 10 mg/kg NX or NTX, except in the case of IMI.”

“Tricyclic antidepressants nortriptyline, chlorimipramine, protiptyline, imipramine and desipramine at a concentration of 10−3 M caused 60–80% inhibition of PDE activity.”

“In the presence of 10−5 M IMI , trains of stimuli at rates between 0.5 and 2 Hz led to an exponential decline in Vmax to a new steady-state level (K = 0.230 ± 0.09 AP−1 at 2 Hz).”

“Chloropromazine (CPZ) and imipramine at a concentration of 1× 10−3 M inhibit rat brain mitochondrial monoamine oxidase activity in vitro by 70 and 55% respectively, while lithium, even at a concentration of 0.05 M, inhibits the activity of this enzyme very negligibly (4%).”

“2 Amitriptyline, nortriptyline, protriptyline, desipramine and imipramine were found to inhibit ATPases at concentrations of 10−5 m and above.”