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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Imipramine
supplement:
Melatonin
Research Papers that Mention the Interaction
“Although in rats chronic imipramine treatment reduced pineal adrenoreceptor binding sites and melatonin levels, in depressed patients chronic treatment with desimipramine results in increases in plasma melatonin levels.”
Monoamines, depression and antidepressant drugs.“After successful treatment with imipramine , 24-hr secretion and peak levels of melatonin were significantly higher than at baseline, with no difference in time of peak level.”
“Although combination of imipramine (40 mg/kg) and melatonin (5 mg/kg) did not exert an antidepressant effect above that of imipramine alone, co-administration of the effective doses (10 and 40 mg/kg for melatonin and imipramine, respectively) displayed an additive effect.”
Combination therapy of imipramine and melatonin: additive antidepressant effect in mouse forced swimming test.“On the other hand, the administration of IPM or APL caused increases in pineal NAS and melatonin.”
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