Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
“Moreover, the joint administration of Mg and imipramine (IMI) at ineffective doses per se, resulted in a potent reduction in the immobility time in this test.”
“ Mg doses ineffective per se (5 and 10 mg/kg) given jointly with IMI also at ineffective doses (10 and 15 mg/kg) resulted in a potent reduction in the immobility time.”
“Moreover administration of IMI increased (normalized) magnesium brain concentration, without influence on the serum level.”
“The present data demonstrated an enhancement of the antidepressant-like effect by joint administration of IMI and magnesium in the FST, and further indicate the particular role of magnesium in the antidepressant action.”
“Mg 2+ ATPase and Na + −K + ATPase activities of the sarcolemmal fraction, whereas imipramine decreased calcium binding, Ca 2+ ATPase and Mg 2 + ATPase activities.”
“In the literature there are reports concerning pharmacological studies in which a potentiation of the effects has been observed after a co-administration of antidepressant imipramine and magnesium.”