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Last Updated: 2 years ago

Possible Interaction: Imipramine and Calcium Supplement

Research Papers that Mention the Interaction

In a series of 57 patients, maintained on constant controlled diets on the Metabolic Unit of the Payne Whitney Clinic, the administration of electric convulsive treatments or imipramine therapy for the alleviation of depression has been associated with significant decreases in the urinary excretion of calcium.
The British journal of psychiatry : the journal of mental science  •  1964  |  View Paper
At concentrations of 5 and 15 μmol/l the effect of imipramine on action potential duration can also be explained by a blocking effect on the high threshold calcium current.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2004  |  View Paper
The calcium induced increase in ATPase and the rate of calcium uptake of the vesicular fragments of sarcoplasmic reticulum isolated from rabbit skeletal muscle are reduced by reserpine, prenylamine, chlorpromazine and imipramine.
Naunyn-Schmiedebergs Archiv für Pharmakologie und experimentelle Pathologie  •  2004  |  View Paper
Imipramine (7.5-30 microM) also inhibited Ca2+ signals in KCl depolarized cells.
Toxicology and applied pharmacology  •  1998  |  View Paper
These results indicated that imipramine inhibited the high K(+)-induced [Ca2+]i increase by the blockade of voltage-dependent Ca2+ channels, and the ACh- and NA-induced ] Ca2+i increases by the blockade of muscarinic receptors and alpha 1-adrenoceptors, respectively.
Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology  •  1991  |  View Paper
Imipramine , chlorpromazine and haloperidol in micromolar concentrations blocked sodium, calcium and potassium channel currents in a reversible and concentration-dependent manner.
Brain Research  •  1989  |  View Paper
Imipramine at both 3 and 25 uM significantly increased the ED50 for calcium.
The Journal of urology  •  1987  |  View Paper
7 It is concluded that even when the effects of Imip are similar to those of quinidine (group I of antiarrythmics), it also produces a reduction in Ca and K conductances.
British journal of pharmacology  •  1983  |  View Paper
Mg 2+ ATPase and Na + −K + ATPase activities of the sarcolemmal fraction, whereas imipramine decreased calcium binding, Ca 2 + ATPase and Mg 2+ ATPase activities.
Biochemical pharmacology  •  1980  |  View Paper
The iCa2+ in ex vivo hippocampus slices stained with fluorescent Ca2+indicator Oregon Green 488 BAPTA-1 revealed that IMI increased the intensity and duration of iCa2+ oscillation and reduced the number of events evoked by glutamate stimuli, evaluated by using CCD imaging and the % ΔF/Fo parameters.
Neurotoxicity research  •  2021  |  View Paper