Possible Interaction: Imipramine and Adrenocorticotropic Hormone

“ Desimipramine (DMI) (50 mg IV) significantly stimulated ACTH secretion.”

“The reduction of immobility, induced by the chronic administration of imipramine for 15 days, was blocked by treatment with ACTH for 14 days.”

“ Imipramine suppressed ACTH , but had minimal effects on corticosterone responses to FST.”

“ ACTH administration has been shown to result in the resistance to acute and chronic effects of imipramine.”

“Relative to vehicle, imipramine potently suppressed adrenocorticotropin hormone (ACTH) responses to FST and restraint exposure.”

“Taken together these results indicate that pre-treatment with ACTH (100μg/day; 14 days) blocks the antidepressant effects of imipramine (10mg/kg), significantly alters key PFC monoamine responses to stress and downregulates glucocorticoid responses.”

“Coadministration of imipramine and lithium for 14 d blocked the loss of cell proliferation but not cell survival resulting from the chronic treatment with ACTH.”

“Secondly, administration of imipramine reduced floating and adrenocorticotropin level without affecting corticosterone.”

“The effect of ACTH was blocked by the administration of imipramine.”

“The reduction of immobility, induced by chronic administration of imipramine , was blocked by treatment with ACTH.”

“This effect of ACTH was significantly increased by the coadministration of carbamazepine and imipramine.”