supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
Research Papers that Mention the Interaction
“After screening their main components, Apigenin strongly inhibited Imp uptake by OAT1/3‐HEK293 cells with IC50 values of 1.98 ± 0.36 μM (OAT1) and 2.29 ± 0.88 μM (OAT3).”
“ Apigenin can be used as a promising agent to reduce the renal adverse reaction of Imp in clinic.”
“ Apigenin inhibited intracellular accumulation of Imp and sequentially decreased the nephrocyte toxicity in rabbit primary proximal tubule cells (rPTCs).”
“Furthermore, Apigenin ameliorated Imp‐induced nephrotoxicity in rabbits, and reduced the renal secretion of Imp.”
“Moreover, Imp exhibited OAT1/3‐dependent cytotoxicity, which was alleviated by Apigenin.”
“Through OAT inhibition, at least in part, Apigenin decreased the renal exposure of Imp and consequently protected against the nephrotoxicity of Imp.”
Targeting renal OATs to develop renal protective agent from traditional Chinese medicines: Protective effect of Apigenin against Imipenem‐induced nephrotoxicity
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback