Possible Interaction: Imidazole and Calcium Supplement

“The coordination bonding was formed between pendant imidazole groups and calcium ions.”

“If diltiazem inhibits the entry of calcium ions into the cells of the growth cartilage, as it does in smooth muscle and myocardial cells, then our results indicate that intracellular concentrations of calcium may play an important role in the accelerated calcification due to imidazole.”

“Prostaglandin inhibitor, sodium meclofenamate, phosphodiesterase inhibitors, aminophylline and dipyridamole, adenosine and blockade of calcium entry by isoptin all reduced the force of spontaneous activity in a concentration-dependent manner, while imidazole enhanced it.”

“ Imidazole , an agent which alters calcium kinetics, blocked the hypothermia response but not the IOP elevation.”

“ Imidazole released Ca from the 35-45% fraction and stimulated its phosphodiesterase activity.”

“Data in the literature indicate that calcium plays a role in the cardiac biochemical and mechanical effects of theophylline and imidazole.”

“Calcium's mitogenic action is inhibited by imidazole , a compound which increases the activity of the cyclic AMP-degrading enzyme phosphodiesterase and thereby also prevents calcium from increasing the cellular cyclic AMP content.”

“Studies carried out in vivo with 45Ca suggested that imidazole inhibited release of calcium from skeletal tissue.”