Possible Interaction: Imatinib and Ginseng

“Based on the Naranjo probability scale, it is probable that imatinib caused this patient's hepatotoxicity, and the Horn drug interaction probability scale also indicates a probable interaction between imatinib and ginseng.”

“CONCLUSIONS: This case emphasizes the importance of continuous monitoring of liver function tests even after several years of imatinib therapy and the importance of advising patients to avoid ginseng and any other over-the-counter herbal supplements that may interact with imatinib.”

“In vivo, ginseng is known to inhibit CYP3A4, the primary enzyme involved in the metabolism of imatinib.”