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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Imatinib
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“In parallel, IM treatment, in vivo and in vitro, were able to modulate the intracellular calcium concentration of peripheral blood mononuclear cells of CML patients by acting at the level of InsP3 receptor in the endoplasmic reticulum and at the level of the purinergic receptors on plasma membrane.”
Imatinib treatment inhibit IL‐6, IL‐8, NF‐KB and AP‐1 production and modulate intracellular calcium in CML patients“However, emerging data suggest that imatinib also targets cells of the skeleton, stimulating the retention and sequestration of calcium and phosphate to bone, leading to decreased circulating levels of these minerals.”
“Our hypothesis is that imatinib alters calcium regulatory mechanisms and can contribute to development of pathological cardiac hypertrophy.”
Imatinib Activates Pathological Hypertrophy by Altering Myocyte Calcium Regulation
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