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Discover Supplement-Drug Interactions

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Last Updated: 3 months ago

Possible Interaction: Ifosfamide and Melatonin

supplement:

Melatonin

Research Papers that Mention the Interaction

Here, we found that there is a synergy in the antitumor effect when melatonin (50 μm–1 mm) is combined with vincristine at the concentration of 5–10 nm or with ifosfamide at the range of 100 μm–1 mm.
There is a significant increase in the activation of caspase‐3, ‐8, ‐9 and Bid when melatonin is combined with vincristine or ifosfamide compared to the individual treatments.
Journal of pineal research  •  2010  |  View Paper
In the kidney, Na+,K+‐ATPase activity which was significantly reduced by IFO , was increased with melatonin treatment.
Melatonin markedly ameliorated the severity of renal dysfunction induced by IFO with a significant decrease in urinary sodium, phosphate, and glucose and increased creatinine excretion.
Journal of pineal research  •  2004  |  View Paper