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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Ifosfamide
supplement:
Melatonin
Research Papers that Mention the Interaction
“Here, we found that there is a synergy in the antitumor effect when melatonin (50 μm–1 mm) is combined with vincristine at the concentration of 5–10 nm or with ifosfamide at the range of 100 μm–1 mm.”
“There is a significant increase in the activation of caspase‐3, ‐8, ‐9 and Bid when melatonin is combined with vincristine or ifosfamide compared to the individual treatments.”
Synergistic antitumor effect of melatonin with several chemotherapeutic drugs on human Ewing sarcoma cancer cells: potentiation of the extrinsic apoptotic pathway“In the kidney, Na+,K+‐ATPase activity which was significantly reduced by IFO , was increased with melatonin treatment.”
“ Melatonin markedly ameliorated the severity of renal dysfunction induced by IFO with a significant decrease in urinary sodium, phosphate, and glucose and increased creatinine excretion.”
Melatonin attenuates ifosfamide‐induced Fanconi syndrome in rats
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