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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“In addition, they suggest that idazoxan and possibly yohimbine act as agonists at the I2 site in kidney.”
Imidazoline Receptors, Subclassification, and Drug‐Induced Regulation“The α2‐adrenoceptor antagonist yohimbine , which possesses affinity for the 5‐HT1D receptor subtype, decreased the release of [3H]5‐HT, but only in the presence of the selective α2‐adrenoceptor antagonist idazoxan , which by itself increased significantly [3H]5‐HT overflow.”
“When we pretreated anaesthetized rabbits, always by intracisternal injections, with identical doses of yohimbine or idazoxan (5 nmoles/kg), we observed that idazoxan prevented much more the hypotensive effects of R than yohimbine.”
“On the other hand, when α2-adrenoceptors were blocked in the presence of yohimbine , exposure to idazoxan (0.1 μmol/l) reduced significantly the stimulation-evoked release of tritium elicited by electrical stimulation.”
Possible involvement of presynaptic α1-adrenoceptors in the effects of idazoxan and prazosin on 3H-noradrenaline release from tail arteries of SHR“Specific alpha-antagonists yohimbine and idazoxan were found to antagonise competitively the effects of NA.”
“While the alpha2-antagonists, yohimbine , rauwolscine and idazoxan blocked NE-induced inhibition in all neurons tested, the prototypical alpha1-antagonist, prazosin produced a variable degree of block (9-58%), further indicating the possible involvement of alpha2A (prazosin-insensitive) and non-alpha2A (prazosin-sensitive) receptors.”
“Moreover, the antinociceptive effects of substance P microinjection appear to be mediated at least in part by activation of spinally projecting noradrenergic neurons in the A7 cell group, because intrathecal injections of the alpha-2 noradrenergic antagonists yohimbine and idazoxan blocked these antinociceptive effects.”
“This effect of idazoxan was mimicked by a further alpha 2 antagonist, yohimbine.”
“Five days idazoxan infusion significantly increased [3H]yohimbine binding in the forebrain, while a significant reduction in [3H]idazoxan binding sites in the kidney was observed.”
“ Idazoxan and yohimbine competitively antagonized the action of noradrenaline with dissociation equilibrium constants of 20 and 30 nM respectively.”
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