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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Idazoxan and Adrenocorticotropic Hormone

drug:

Idazoxan

supplement:

Adrenocorticotropic Hormone

Research Papers that Mention the Interaction

“Intracerebroventricular (icv) application of idazoxan , significantly increased the ACTH response to swim stress in virgin females, but had the opposite effect in lactating females.”
Reduced Noradrenergic Tone to the Hypothalamic Paraventricular Nucleus Contributes to the Stress Hyporesponsiveness of Lactation
Journal of neuroendocrinology  •  1998  |  View Paper
“Injection of 2.5 micrograms/g idazoxan induced a rapid (within 30 min) increase in basal plasma ACTH and corticosterone levels that lasted for 60 min.”
“Injection of increasing doses of idazoxan led to a dose-dependent stimulation of ACTH and corticosterone levels.”
Blockade of alpha 2-adrenoceptors stimulates basal and stress-induced adrenocorticotropin secretion in the developing rat through a central mechanism independent from corticotropin-releasing factor and arginine vasopressin.
Endocrinology  •  1994  |  View Paper