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Last Updated: 3 months ago

Possible Interaction: Idarubicin and Tretinoin

supplement:

Tretinoin

Research Papers that Mention the Interaction

CONCLUSIONS The combination of all-trans-retinoic acid and just two cycles of idarubicin followed by triple maintenance produced durable remissions in most patients, but patients with high-risk disease, especially those with FLT3 mutations, require additional agents or alternative treatment approaches.
CONCLUSIONS The combination of all-trans-retinoic acid and just two cycles of idarubicin followed by triple maintenance produced durable remissions in most patients, but patients with high-risk disease, especially those with FLT3 mutations, require additional agents or alternative treatment approaches.
Haematologica  •  2012  |  View Paper
We present an analysis of the incidence, characteristics, prognostic factors, and outcome of 739 APL patients treated with ATRA plus idarubicin in 2 consecutive trials (Programa Español de Tratamientos en Hematología [PETHEMA] LPA96 and LPA99).
Blood  •  2009  |  View Paper
From November 1999 through July 2005 (LPA99 trial), 560 patients received induction therapy with ATRA plus idarubicin.
Blood  •  2008  |  View Paper
“If it turns out idarubicin plus ATRA is better than what we did, then that’s the end of arsenic for newly diagnosed patients,” Estey said.
Journal of the National Cancer Institute  •  2007  |  View Paper
Here we describe three unusual cases of CNS relapses out of 60 APL treated with ATRA plus idarubicin (AIDA 2000 protocol) in our Division from 1993.
Haematologica  •  2006  |  View Paper
Although the reduction of early fatal haemorrhages was not significant, a substantial clinical improvement was evident in terms of reduction of the severity of bleeding symptoms, blood product consumption and overall induction mortality when ATRA was combined with idarubicin.
British journal of haematology  •  2000  |  View Paper
A 72 h pre-incubation with retinoids was able to further increase the cytotoxicity of ATRA plus idarubicin in the two cell lines.
Both in HL-60 and in K562 cells, the majority of the combinations of ATRA and idarubicin were synergistic, while the combinations with 9-cis-RA and 13-cis-RA were more effective in HL-60 and K562 cells, respectively.
In this study we aimed at investigating the rationale of the combination of ATRA plus idarubicin in two human leukemic cell lines, HL-60 and K562, that display a different sensitivity to ATRA treatment.
Intracellular idarubicin accumulation was enhanced by retinoids , as demonstrated by a cytofluorimetric method.
Our results could contribute to provide a rationale for ATRA plus idarubicin combinations not only in APL but also in acute leukemia of other cytotypes.
Anti-cancer drugs  •  1996  |  View Paper