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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Idarubicin
supplement:
Tretinoin
Research Papers that Mention the Interaction
“Conclusions The combination of all-trans-retinoic acid and just two cycles of idarubicin followed by triple maintenance produced durable remissions in most patients, but patients with high-risk disease, especially those with FLT3 mutations, require additional agents or alternative treatment approaches.”
Results of the APML3 trial incorporating all-trans-retinoic acid and idarubicin in both induction and consolidation as initial therapy for patients with acute promyelocytic leukemia“Of 372 patients attaining complete remission after ATRA plus idarubicin (92.5%), 368 proceeded to consolidation therapy.”
“We present an analysis of the incidence, characteristics, prognostic factors, and outcome of 739 APL patients treated with ATRA plus idarubicin in 2 consecutive trials (Programa Español de Tratamientos en Hematología [PETHEMA] LPA96 and LPA99).”
“From November 1999 through July 2005 (LPA99 trial), 560 patients received induction therapy with ATRA plus idarubicin.”
“Here we describe three unusual cases of CNS relapses out of 60 APL treated with ATRA plus idarubicin (AIDA 2000 protocol) in our Division from 1993.”
“The GIMEMA (Gruppo Italiano Malattie Emetologiche dell'Adulto) group recently reported a significantly higher proportion of relapses in the CNS when ATRA was added to idarubicin for induction in APL (Specchia, 1999).”
“A 72 h pre-incubation with retinoids was able to further increase the cytotoxicity of ATRA plus idarubicin in the two cell lines.”
“Both in HL-60 and in K562 cells, the majority of the combinations of ATRA and idarubicin were synergistic, while the combinations with 9-cis-RA and 13-cis-RA were more effective in HL-60 and K562 cells, respectively.”
“In this study we aimed at investigating the rationale of the combination of ATRA plus idarubicin in two human leukemic cell lines, HL-60 and K562, that display a different sensitivity to ATRA treatment.”
“Intracellular idarubicin accumulation was enhanced by retinoids , as demonstrated by a cytofluorimetric method.”
“Our results could contribute to provide a rationale for ATRA plus idarubicin combinations not only in APL but also in acute leukemia of other cytotypes.”
“The use of idarubicin in combination with ATRA would favour the process of producing a peeling effect.”
Miliaria crystallina induced by idarubicin and all‐trans‐retinoic acid: Two case reports
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