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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Ibuprofen and Melatonin

supplement:

Melatonin

Research Papers that Mention the Interaction

Previous studies showed that nonsteroidal anti-inflammatory drugs such as ibuprofen and indomethacin suppress melatonin secretion and alter the circadian rhythm [6].
Rheumatology International  •  2014  |  View Paper
Administration of ibuprofen (400 mg) at 1800h delayed the nocturnal surge of plasma MT.
Ibuprofen reduced human plasma melatonin ( MT ) after 2 h when administered orally (400 mg) at 2400h.
The Journal of pharmacy and pharmacology  •  1987  |  View Paper