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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Ibuprofen
supplement:
Epigallocatechin Gallate
Research Papers that Mention the Interaction
“Epigallocatechin‐3‐gallate EGCG ) and ibuprofen synergistically act to suppress proliferation and enhance apoptosis of prostate cancer cell lines, PC‐3 and LNCaP. The purpose of this study was to investigate the mechanism of underlying this synergism.”
“In both cell lines, EGCG + ibuprofen inhibited cell proliferation synergistically.”
“…,EGCG + ibuprofen treatment in PC‐3 cells resulted in altering the ratio of the splice variants of Bcl‐X and Mcl‐1, downregulating the mRNA levels …(L) and Mcl‐1(L) with a concomitant increase in the mRNA levels of pro‐apoptotic Bcl‐X(s) and Mcl‐1(s).”
Protein phosphatase 1 activation and alternative splicing of Bcl‐X and Mcl‐1 by EGCG + ibuprofen
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