Possible Interaction: Ibandronate and Calcium Supplement

“On day 0, 15 normocalcemic breast cancer patients with bone metastases … mg of ibandronate injected intravenously over 60–120 s. Ibandronate treatment led to … levels of calcium (p < 0.0001) and phosphate (p < 0.0001) and to subsequent … of parathyroid hormone (p < 0.0001) and calcitriol (p < 0.0001).”

“Besides, ibandronate treatment caused a significant increase in calcium load and a decrease in calcium spark amplitude, while spark intensity was rebounding during washout.”

“In terms of percentage BMD change at the femoral neck, both pamidronate and ibandronate combined with calcium demonstrated a remarkable gain compared with calcium (MD, 7.02; 95% CrI, 0.30–13.29 and MD, 7.30; 95% CrI, 0.32–14.22, respectively).”

“The combination of ibandronate with calcium displayed a significant increase in absolute BMD compared to any other treatments and was ranked best.”

“ Calcium and calcitriol supplementation alone showed an excellent efficacy and safety profile, virtually maintaining BMD without any loss over 12 months after renal transplantation, whereas adding ibandronate significantly improved BMD in total femur and ultradistal radius, and also suppressed biomarkers of bone turnover.”

“The growth inhibitory effect of ibandronate in the presence of high concentrations of calcium was partly suppressed by the calcium chelator EGTA (ethylene glycol tetra-acetic acid).”

“Following sigmacystoplasty, bone calcium content was significantly decreased; this could be prevented by ibandronate.”