Possible Interaction: Hypochlorite and Vitamin C

“Redox homeostasis between hypochlorous acid (HClO/ClO-) and ascorbic acid (AA) significantly impacts many physiological and pathological processes.”

“ Vitamin C lessened this inhibitory effect of hypochlorite on PON1 activities.”

“We tested the hypothesis that vitamin C protects HDL and PON1 from deleterious effects of hypochlorous acid , a proinflammatory oxidant.”

“For example, vitamin C effectively inhibits lipid and protein oxidation in human plasma exposed to various (patho)physiologically relevant types of oxidative stress, such as activated polymorphonuclear leukocytes, reagent or myeloperoxidase-derived hypochlorous acid , cigarette smoke, or redox-active iron or copper ions (1,3).”

“As HOCl-mediated LDL modifications have been strongly implicated in the pathogenesis of atherosclerosis, our data indicate that vitamin C could contribute to the anti-atherogenic defence against HOCl.”

“Co-incubation of vitamin C (25-200 microM) with LDL resulted in concentration-dependent protection against HOCl (25-200 microM)-mediated oxidation of tryptophan and lysine residues, formation of chloramines and increases in the relative electrophoretic mobility of LDL.”

“Acta 784, 189‐191] observed that micromolar concentrations of ascorbic acid prevented inactivation of myeloperoxidase and increased the production of hypochlorous acid , we examined whether ascorbic acid would augment singlet oxygen production by the myeloperoxidase‐hydrogen peroxide‐halide ion systems.”

“The effects of HOCl could be blocked by coadministration of antioxidants, i.e., N-acetylcystein (NAC), uric acid (UA) and ascorbic acid (AA).”

“ Vitamin C blocked epithelial damage caused by 30 mM HOCl.”