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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Hypochlorite
supplement:
Ascorbate
Research Papers that Mention the Interaction
“ Hypochlorous acid , ONOO(-) and O(2)(*-) react with ascorbate , which is essential for cartilage function, leading to low levels of ascorbate in synovial fluid.”
The role of free radicals in the pathogenesis of rheumatoid arthritis.“In this study, rate constants (M(-1) s(-1)) for the reactions of ascorbate with HOCl (ca.”
“The anti-oxidants ascorbate and cysteine (50 μM), when added to MNL prior to exposure to HOCl (25 μM), prevented the anti-proliferative effects of the oxidising agent.”
“The latent gingival crevicular fluid collagenase was also activated by HOCl and this activation could be prevented by ascorbate.”
“However, addition of HOCl to the DNA preoxidized with an oxidant-generating system (CuCl2, ascorbate , H2O2), led to the extensive loss of 8-oxo-dG due to its further oxidation.”
Epigallocatechin gallate markedly enhances formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine in the reaction of 2'-deoxyguanosine with hypochlorous acid.“Amino acids and ascorbate reacted with hypochlorite much faster than peroxides.”
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