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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Hypericin
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“In contrast, stimulation with higher concentrations of hypericin (1–5 µM) led to a rapid decrease in Ca <sup>2+</sup> influx and [Ca<sup>2+</sup>]<sub>i</sub>, which was significantly different from those detected without hypericin (control experiments).”
“Stimulation with hypericin, which was applied immediately after preincubation with PMA for …+</sup>]<sub>i</sub>. Conclusion: In RPE cells, high concentrations of hypericin (… Ca <sup>2+</sup> influx and induce a decrease in [Ca<sup>2+</… maybe through its inhibition of the Ca<sup>2+</sup> influx pathway.”
The Inhibition of Ca2+ Influx Induced by Hypericin in Cultured Human Retinal Pigment Epithelial Cells Analyzed by Confocal Imaging“Both compounds increased the oral bioavailability of hypericin by ca.”
Plasma levels of hypericin in presence of procyanidin B2 and hyperoside: a pharmacokinetic study in rats.“The results show that hypericin inhibits the release of arachidonic acid (AA) from membrane phospholipids in calcium ionphore A23187-TPA stimulated human granulocytes in a dose-dependent manner (IC(50) 4 μM), but that calcium ionophore is not the only inducer.”
Immunosuppressive effects of hypericin on stimulated human leukocytes: inhibition of the arachidonic acid release, leukotriene B(4) and Interleukin-Iα production, and activation of nitric oxide formation.
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