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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Hydroxyurea
supplement:
Iron, Dietary
Research Papers that Mention the Interaction
“It is also suggested … and labile forms of Fe or Cu ions, such as non transferrin-bound iron (NTBI) or intracellular low molecular weight …, are among the main factors that may cause variations in the therapeutic response to HU in cancer, sickle cell anemia, … and other groups of patients.”
Interactions Of Hydroxycarbamide (Hydroxyurea) With Iron And Copper: Implications On Toxicity and Therapeutic Strategies“Inhibition of ribonucleotide reductase/DNA synthesis by hydroxyurea results in a decrease in iron uptake by cells and an increase in the activity of the iron-regulatory protein, which, in turn, is responsible for the hydroxyurea-induced increase in transferrin receptor and decrease in ferritin synthesis.”
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