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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Hydroxyurea
supplement:
Ferric Ion
Research Papers that Mention the Interaction
“Presented at the 19th International Conference on Chelation, London, UK, … November 2009Preliminary spectrophotometric and potentiometric studies have shown that hydroxycarbamide or hydroxyurea (HU) can interact with copper(…(II)], iron(II) [Fe(II)] and Fe(III) ions and form complexes, for example, a ratio … HU:1 metal at pH 5.”
Interactions Of Hydroxycarbamide (Hydroxyurea) With Iron And Copper: Implications On Toxicity and Therapeutic Strategies“In the presence of Fe(III) and reductants, less inhibition of enzymatic activity by hydroxyurea was observed, especially for p53R2/hRRM1.”
“The presence of Fe++ blocked completely the cytotoxic action of HU alone and a combination with iron-chelator, and partially reversed the inhibition induced by HU and bipyridyl.”
Sensitization of P388 murine leukemia cells to hydroxyurea cytotoxicity by hydrophobic iron-chelating agents.
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