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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Hydroxyproline
drug:
Spironolactone
Research Papers that Mention the Interaction
“The mineralocorticoid receptor antagonist, spironolactone , severely attenuates pouch formation over a 2-week period and significantly reduces pouch wall hydroxyproline concentration.”
Extra-adrenal mineralocorticoids and cardiovascular tissue.“1) Ex vivo lung slice rat experiments found that eplerenone (0.01 and 10 µM) and spironolactone (10 µM) diminished lung hydroxyproline concentrations by 55 ± 5, 122 ± 9, and 83 ± 8%. (”
“increased lung levels of hydroxyproline by approximately 155%, which was blocked by spironolactone (10-60 mg/kg, p.o.).”
Mineralocorticoid receptor antagonists attenuate pulmonary inflammation and bleomycin-evoked fibrosis in rodent models.“Compared with controls, hydroxyproline concentration was significantly reduced following spironolactone treatment (17.1 ± 0.08 vs. 7.5 ± 2.0 μg/mg dry wt, respectively, p < 0.01).”
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