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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Hydroxyproline
drug:
Sirolimus
Research Papers that Mention the Interaction
“Treatment with rapamycin reduced hydroxyproline content compared with the control diet (irradiation plus vehicle, 45.9 ± 11.8 μg per lung; irradiation plus rapamycin, 21.4 ± 6.0 μg per lung; P=.001) and reduced visible fibrotic foci.”
Mammalian Target of Rapamycin Inhibition With Rapamycin Mitigates Radiation-Induced Pulmonary Fibrosis in a Murine Model.“The hydroxyproline content and the fibroblast density in the 0.2 mg/ml and 0.1 mg/ml RAPA groups were significantly less than those of the control group.”
“Significant inhibition of alveolitis and hydroxyproline product were demonstrated when daily administration of rapamycin lasted for at least 14 days.”
“Early and late SRL also caused a decrease in HPL content (p=0.001).”
“The tensile strength and the hydroxyproline levels in the biliary anastomosis were lower in the animals treated with rapamycin.”
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