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“In addition, substitution of hydroxyproline residues in APHCP with prolines impaired its anti-HIV-1 activity, suggesting that the hydroxyl group of hydroxyprolines is required for the anti-HIV-1 activity of APHCP.”
Toxicon : official journal of the International Society on Toxinology • 2009 | View Paper
“ Cis‐hydroxyproline , an analog of proline known to prevent the proper folding of triple helical collagen molecules, inhibited the response of sandwiched hepatocytes to proline in a dose‐dependent and reversible manner.”
Comparative biochemistry and physiology. B, Comparative biochemistry • 1974 | View Paper
“When calli were cultured on 4 mM Hyp medium for 7 days, intracellular Pro content of the HR calli was five times higher than that detected in the normal calli.”
“Two analogues of proline, thioproline and hydroxyproline, also enhanced cell elongation but whereas the effect of hydroxyproline was completely prevented by proline , the stimulation produced by thioproline was not.”