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Last Updated: 2 years ago

Possible Interaction: Hydroxyproline and Pirfenidone

Research Papers that Mention the Interaction

Moreover, pirfenidone effectively decreased hydroxyproline levels in orbital fibroblasts, whereas dexamethasone had no effect on hydroxyproline levels.
Investigative ophthalmology & visual science  •  2010  |  View Paper
Additionally, pirfenidone significantly reduced expression of αSMA 12 days after the induction of burns and modestly reduced hydroxyproline in 22-day-old burn wounds.
Inflammation  •  2018  |  View Paper
PF significantly decreased the lung fibrosis and edema, inflammatory cells infiltration, TGF-β1 concentration, and amount of hydroxyproline in the lung tissue.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association  •  2018  |  View Paper
PFD attenuated body weight, heart weight, left ventricular weight, left ventricular systolic pressure, and ±dp/dtmax changes induced by MI, which were associated with a reduction in cardiac fibrosis, infarct size, and hydroxyproline concentration.
Scientific reports  •  2017  |  View Paper
Pirfenidone solution and NPs significantly reduced hydroxyproline levels by 57 and 81%, respectively, compared to bleomycin alone.
Nanotechnology  •  2012  |  View Paper
Pirfenidone treatment resulted in a significant reduction in the level of hydroxyproline concentration across all muscles, although the effect was small.
Muscle & nerve  •  2007  |  View Paper
Treatment with PD for 37 days caused significant reductions in the vanadate-induced increases in the hydroxyproline level.
Biochemical pharmacology  •  2002  |  View Paper
Pirfenidone ingestion significantly attenuated these bleomycin-induced pertubations in pulmonary functions and lung hydroxyproline levels (BCD versus BPD).
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine  •  1997  |  View Paper
Total lung hydroxyproline content, an index of fibrosis, was significantly lower 21 days after treatment with CP plus pirfenidone as compared to mice treated with CP alone.
Toxicology letters  •  1997  |  View Paper