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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Hydroxyproline
drug:
Perindopril
Research Papers that Mention the Interaction
“The hepatic hydroxyproline , serum fibrosis markers, alpha-smooth muscle actin (alpha-SMA) immunopositive cells in number, and alpha-(III) pro-collagen mRNA expression were significantly suppressed by PE treatment.”
Inhibition of renin-angiotensin system attenuates liver enzyme-altered preneoplastic lesions and fibrosis development in rats.“The hepatic hydroxyproline and serum fibrosis markers were significantly suppressed by CA and PE treatment.”
“With regard to the … 2 mg/kg perindopril had no inhibitory effects on the progression of …, but at 8 mg/kg, it reduced hepatic hydroxyproline contents by 63%, collagen-I mRNA by 94%, TGF-β1 mRNA by … mRNA by 97% and tissue inhibitor of metalloproteinase-1 mRNA by 87%.”
“With regard to … preventative effects, perindopril reduced … hepatic hydroxyproline content by 33%, collagen-I mRNA by 38%, α-smooth muscle actin (α-SMA)-positive cells by 46%, α-SMA … by 40%, transforming growth factor-β1 (TGF-β1) mRNA by 21% and connective tissue growth factor (CTGF) mRNA by 27%.”
Preventative and therapeutic effects of perindopril on hepatic fibrosis induced by bile duct ligation in rats.
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