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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Hydroxyproline
drug:
Indomethacin
Research Papers that Mention the Interaction
“It was found that indomethacin reduced the release of calcium, inorganic phosphate and hydroxyproline without affecting the total amount of hydroxyproline in the cultures.”
“The inhibition of the release of hydroxyproline and minerals could be seen in concentrations of indomethacin from 10−5 to 10−8M.”
Indomethacin inhibits bone resorptionin vitro without affecting bone collagen synthesis“The study shows that in vitro calcium and hydroxyproline resorption in the unstimulated mouse calvaria are inhibited by indomethacin at concentrations measured in serum during human therapy.”
“Total hydroxyproline synthesis and incorporation of hydroxyproline into collagen were found to be significantly increased after indomethacin treatment, whereas no significant difference was found regarding collagen resorption.”
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