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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Hydroxyproline
supplement:
Ascorbate
Research Papers that Mention the Interaction
“Incubation with ascorbate (100 #g/ml) resulted in increased hydroxyproline content of the matrix digests.”
Rapid estimation of collagen in a dermal model“ Ascorbate supplementation (50 micrograms/mL) to confluent fibroblasts cultured from the two patients and controls increased hydroxyprolyl and hydroxylysyl residues of fibroblasts four to seven and three to four-fold respectively.”
“Urinary excretion of hydroxylysine and hydroxyproline increased during ascorbate administration.”
“Only when the ascorbate concentration in the tissue was less than 6 micrograms/g wet weight (compared with 50-70 micrograms/g wet weight in fresh tissue), was hydroxyproline formation reduced by 75-85%.”
Ascorbic acid requirements for collagen synthesis (proline hydroxylation) during long-term culture of embryonic chick femurs.“Addition of ascorbate to the cultures increased the rate of synthesis of procollagen hydroxyproline , but the effect was not explained by activation of prolyl hydroxylase as has been seen in other cell cultures.”
“In cultured cells, ascorbate at a concentration of 40 mug per ml caused a 2-fold increase in the rate of hydroxyproline synthesis within 30 min.”
“There have been many reports”-l-* that the amount of hydroxyproline formed by cultured fibroblasts and osteoblasts is increased by treatment with ascorbate.”
ACTIVATION OF PROLYL HYDROXYLASE IN FIBROBLASTS BY ASCORBIC ACID
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