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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Hydroxyproline
drug:
Alendronate
Research Papers that Mention the Interaction
“ Alendronate induced a marked suppression in the urinary excretion of hydroxyproline within 2 weeks (p < 0.01) followed by a fall in serum activity of alkaline phosphatase at 1 month (p < 0.01) in all treatment groups.”
“A significant reduction in the mean fasting urinary excretion of hydroxyproline occurred within 2 days of starting treatment, reaching a nadir at 2–4 weeks, which was most marked in patients receiving 10 mg of alendronate (p < 0.05).”
“ Alendronate , 10 mg/day for 5 days, suppressed urinary hydroxyproline to 44.9 ± 4.8% and serum alkaline phosphatase to 74.6 ± 5.4% of their pretreatment values within 1 month of the start of treatment.”
“In the nine patients who had not been treated previously with bisphosphonates, the short course of AHButBP induced a suppression of serum alkaline phosphatase and urinary hydroxyproline values down to 30% of initial values.”
Treatment of Paget's disease of bone with intravenous 4-amino-1-hydroxybutylidene-1,1-bisphosphonate
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